Anticorps Polyclonal de lapin anti-Leiomodin-2

Leiomodin-2 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, porc, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 31202-1-PBS

Synonymes

LMOD2, Leiomodin 2, Cardiac leiomodin, C LMOD

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Galerie de données de validation

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  WB analysis using 31202-1-AP (same clone as 31202-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 31202-1-AP (LMOD2 antibody) at dilution of 1:15000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 31202-1-PBS in a different storage buffer formulation.

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Informations sur le produit

31202-1-PBS cible Leiomodin-2 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, porc, rat, souris

• Réactivité: Humain, porc, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Leiomodin-2 Protéine recombinante Ag35312
• Nom complet: leiomodin 2 (cardiac)
• Masse moléculaire calculée: 62 kDa
• Poids moléculaire observé: 70-100 kDa
• Numéro d’acquisition GenBank: NM_207163.2
• Symbole du gène: LMOD2
• Identification du gène (NCBI): 442721
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Leiomodin-2 (Lmod2) is a striated muscle-specific actin-binding protein that plays a crucial role in the regulation of thin filament length and assembly in muscle cells. It is particularly important in cardiac and skeletal muscles. In the heart, Lmod2 is necessary for maintaining proper thin filament length, which is crucial for generating contractile force. Studies have shown that Lmod2 knockout in mice leads to dilated cardiomyopathy and rapid cardiac failure due to shorter and non-uniform thin filaments. Lmod2 is also essential for effective skeletal muscle contraction. Mutations or loss of Lmod2 can lead to significant impairments in muscle function. Mutations in the LMOD2 gene have been linked to severe neonatal and infantile dilated cardiomyopathy, a condition characterized by enlarged heart chambers and impaired contractility. Its observed molecular weight is 70-100 kDa.

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