Anticorps Recombinant de lapin anti-MACROD1

MACROD1 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

241506C1

N° de cat : 84398-3-PBS

Synonymes

EC:3.2.2.-, EC:3.1.1.106, ADP-ribose glycohydrolase MACROD1, 241506C1, [Protein ADP-ribosylglutamate] hydrolase MACROD1

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Galerie de données de validation

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  WB analysis using 84398-3-RR (same clone as 84398-3-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84398-3-RR (MACROD1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84398-3-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 84398-3-RR

  Biolayer interferometry (BLl) kinetic assays of 84398-3-RR against Human MACROD1 were performed. The affinity constant is 11.1 nM.

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Informations sur le produit

84398-3-PBS cible MACROD1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: MACROD1 Protéine recombinante Ag34080
• Nom complet: MACRO domain containing 1
• Masse moléculaire calculée: 325 aa, 36 kDa
• Poids moléculaire observé: 28 kDa
• Numéro d’acquisition GenBank: BC008316
• Symbole du gène: MACROD1
• Identification du gène (NCBI): 28992
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

MACRO domain containing 1 (Macrod1) is also named as LRP16. Macrod1 is an ADP-ribosylhydrolase 1 that is highly enriched in mitochondria, participating in the pathogenesis of cardiovascular diseases (PMID: 38459256). MacroD1 was recruited to the sites of DNA damage via recognition of ADP-ribosylation at DNA lesions (PMID: 32683309). MacroD1 is highly expressed in human and mouse skeletal muscle (PMID: 29410655). Macrod1 may play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation (PMID: 17893710, PMID: 17914104). Macrod1 could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells (PMID: 17893710).

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