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Anticorps Polyclonal de lapin anti-MAPKAP1

MAPKAP1 Polyclonal Antibody for ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

ELISA

Conjugaison

Non conjugué

N° de cat : 20993-1-AP

Synonymes

JC310, MAPKAP1, MIP1, mSIN1, SAPK interacting protein 1, SIN1, SIN1b, SIN1g, TORC2 subunit MAPKAP1

Galerie de données de validation

Applications testées

Dilution recommandée

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

20993-1-AP cible MAPKAP1 dans les applications de ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène Peptide
Nom complet mitogen-activated protein kinase associated protein 1
Masse moléculaire calculée 59 kDa
Numéro d’acquisition GenBankNM_024117
Symbole du gène MAPKAP1
Identification du gène (NCBI) 79109
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3
Conditions de stockageStocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20oC Les 20ul contiennent 0,1% de BSA.

Informations générales

MAPKAP1, also named as MIP1 and SIN1, belongs to the SIN1 family. It is a subunit of mTORC2 which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. It inhibits HRAS and KRAS signaling. MAPKAP1 enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. The antibody is specific to MAPKAP1. The antibody can recognize all the isoform of MAPKAP1.