Anticorps Recombinant de lapin anti-MAdCAM1

MAdCAM1 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

242902D6

N° de cat : 98444-1-PBS

Synonymes

Adhesion molecule immunoglobulin-like domain-containing protein, MAdCAM-1

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Galerie de données de validation

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  FC experiment of Transfected HEK-293T using 98444-1-RR (same clone as 98444-1-PBS)

  1x10^6 HEK-293T or MAdCAM1-transfected HEK-293T cells were surface stained with 0.25 ug Anti-Mouse MAdCAM1 Rabbit RecAb (98444-1-RR, Clone: 242902D6) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98444-1-PBS in a different storage buffer formulation.

• 

  FC experiment of Transfected HEK-293T using 98444-1-RR (same clone as 98444-1-PBS)

  1x10^6 HEK-293T or MAdCAM1-transfected HEK-293T cells were surface stained with 0.25 ug Anti-Mouse MAdCAM1 Rabbit RecAb (98444-1-RR, Clone: 242902D6) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98444-1-PBS in a different storage buffer formulation.

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Informations sur le produit

98444-1-PBS cible MAdCAM1 dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: MAdCAM1 Protéine recombinante Eg2010
• Nom complet: mucosal vascular addressin cell adhesion molecule 1
• Masse moléculaire calculée: 44kDa
• Numéro d’acquisition GenBank: NP_038619
• Symbole du gène: Madcam1
• Identification du gène (NCBI): 17123
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

Lymphocyte recirculation through different organs is thought to be regulated by adhesion molecules ("homing receptors") recognizing tissue-specific vascular addressins on endothelium (PMID: 7511642). The mucosal vascular addressin, MAdCAM1, is an immunoglobulin superfamily adhesion receptor for lymphocytes that is expressed by mucosal venules and helps direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria (PMID: 7687523). MAdCAM1 can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes.

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