Anticorps Recombinant de lapin anti-MCOLN3

MCOLN3 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

250799F8

N° de cat : 86202-1-PBS

Synonymes

Mucolipin 3, Transient receptor potential channel mucolipin 3, TRP ML3, TRPML3

---

Galerie de données de validation

• 

  WB analysis using 86202-1-RR (same clone as 86202-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 86202-1-RR (MCOLN3 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86202-1-PBS in a different storage buffer formulation.

• 

  Affinity and Kinetic Characterization of 86202-1-RR

  Biolayer interferometry (BLl) kinetic assays of 86202-1-RR against Human MCOLN3 were performed. The affinity constant is 0.18 nM.

---

Informations sur le produit

86202-1-PBS cible MCOLN3 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: MCOLN3 Protéine recombinante Ag4962
• Nom complet: mucolipin 3
• Masse moléculaire calculée: 64 kDa
• Poids moléculaire observé: 80 kDa
• Numéro d’acquisition GenBank: BC060765
• Symbole du gène: MCOLN3
• Identification du gène (NCBI): 55283
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

MCOLN3 (Mucolipin 3) is a member of the TRPML (Transient Receptor Potential Mucolipin) gene family and encodes a non-selective cation channel protein that is primarily localized on the membranes of endosomes and lysosomes. MCOLN3 promotes endosome acidification, regulates membrane transport and fusion, and is involved in the autophagy process. Additionally, MCOLN3 is involved in the regulation of intracellular calcium (Ca²⁺) and iron (Fe²⁺) ion homeostasis, maintains lysosomal membrane potential, promotes endosome-lysosome fusion and material transport (such as autophagy), and may also be involved in neuronal signaling and immune regulation.

{{ptg:RelatedPrimaryAntibodies}}