Anticorps Monoclonal anti-MCRS1

MCRS1 Monoclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

2H10E10

N° de cat : 60215-1-PBS

Synonymes

58 kDa microspherule protein, ICP22BP, INO80 complex subunit J, INO80Q, MCRS1, MCRS2, microspherule protein 1, MSP58, P78

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Galerie de données de validation

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  WB analysis of ROS1728 using 60215-1-Ig (same clone as 60215-1-PBS)

  ROS1728 cells were subjected to SDS PAGE followed by western blot with 60215-1-Ig (MCRS1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60215-1-PBS in a different storage buffer formulation.

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  WB analysis of U2OS using 60215-1-Ig (same clone as 60215-1-PBS)

  U2OS cells were subjected to SDS PAGE followed by western blot with 60215-1-Ig (MCRS1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60215-1-PBS in a different storage buffer formulation.

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Informations sur le produit

60215-1-PBS cible MCRS1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Mouse / IgG2a
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: MCRS1 Protéine recombinante Ag1904
• Nom complet: microspherule protein 1
• Masse moléculaire calculée: 51 kDa
• Poids moléculaire observé: 55+110 kDa
• Numéro d’acquisition GenBank: BC011794
• Symbole du gène: MCRS1
• Identification du gène (NCBI): 10445
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

MCRS1, also named INO80Q, MSP58 or p78, is a nucleolar protein expressed in the very early S phase. It modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. MCRS1 is also present on polyribosomes of synaptoneurosome as a novel RNA-binding protein to activate the rRNA transcription. The forkhead-associated domain of MCRS1 is involved in association with centrosomal protein Nde1, comprising a component of the centrosome and taking an essential role in viability. Its isoform MCRS2 might be a linker between telomere maintenance and cell-cycle regulation by interacting with LPTS/PinX1, a telomerase-inhibitory protein. MCRS1 is detected by Western blot as a highly modified protein at 78 kDa and minor bands at about 62 and 55 kDa.

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