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Anticorps Recombinant de lapin anti-M-CSF

M-CSF Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

241743C5

N° de cat : 84481-4-PBS

Synonymes

M CSF, Lanimostim, CSF-1, CSF1, CSF 1

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using M-CSF Recombinant antibody (84481-4-RR)

    WB analysis using 84481-4-RR (same clone as 84481-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84481-4-RR (MCSF antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84481-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84481-4-RR

    Affinity and Kinetic Characterization of 84481-4-RR

    Biolayer interferometry (BLl) kinetic assays of 84481-4-RR against Human M-CSF were performed. The affinity constant is 11.4 nM.

Informations sur le produit

84481-4-PBS cible M-CSF dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Lapin / IgG
Clonalité Recombinant
Type Anticorps
Immunogène Protéine recombinante
Nom complet colony stimulating factor 1 (macrophage)
Masse moléculaire calculée 60 kDa
Poids moléculaire observé60 kDa
Numéro d’acquisition GenBankBC021117
Symbole du gène M-CSF
Identification du gène (NCBI) 1435
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Protein A purfication
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

M-CSF plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes. M-CSF promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. It also plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. On the cellular level, M-CSF promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration and plays a role in lipoprotein clearance (PMID: 29734839; 29679908; 28202039)

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