Anticorps Polyclonal de lapin anti-MDC1

MDC1 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 22272-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis of HeLa using 22272-1-AP (same clone as 22272-1-PBS)

  HeLa cells were subjected to SDS PAGE followed by western blot with 22272-1-AP (MDC1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22272-1-PBS in a different storage buffer formulation.

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  WB analysis using 22272-1-AP (same clone as 22272-1-PBS)

  Total HEK-293 cells and HEK-293 nuclear extract lysates were subjected to SDS PAGE followed by western blot with 22272-1-AP (MDC1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22272-1-PBS in a different storage buffer formulation.

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Informations sur le produit

22272-1-PBS cible MDC1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: mediator of DNA damage checkpoint 1
• Masse moléculaire calculée: 227 kDa
• Poids moléculaire observé: ~260 kDa
• Numéro d’acquisition GenBank: NM_014641
• Symbole du gène: MDC1
• Identification du gène (NCBI): 9656
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

MDC1, also named as KIAA0170 or NFBD1, is a 2089 amino acid protein, which contains two BRCT domains and one FHA domain. MDC1 localizes in the nucleus and is highly expressed in testis. MDC1 is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. MDC1 may serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked.

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