- Phare
- Validé par KD/KO
Anticorps Recombinant de lapin anti-METTL14
METTL14 Recombinant Antibody for WB, IHC, Indirect ELISA
Hôte / Isotype
Lapin / IgG
Réactivité testée
Humain, rat, souris
Applications
WB, IHC, Indirect ELISA
Conjugaison
Non conjugué
CloneNo.
2E7
N° de cat : 80790-1-PBS
Synonymes
Galerie de données de validation
Informations sur le produit
80790-1-PBS cible METTL14 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris
Réactivité | Humain, rat, souris |
Hôte / Isotype | Lapin / IgG |
Clonalité | Recombinant |
Type | Anticorps |
Immunogène | METTL14 Protéine recombinante Ag14325 |
Nom complet | methyltransferase like 14 |
Masse moléculaire calculée | 456 aa, 52 kDa |
Poids moléculaire observé | 55-60 kDa |
Numéro d’acquisition GenBank | BC007449 |
Symbole du gène | METTL14 |
Identification du gène (NCBI) | 57721 |
Conjugaison | Non conjugué |
Forme | Liquide |
Méthode de purification | Purification par protéine A |
Tampon de stockage | PBS only |
Conditions de stockage | Store at -80°C. 20ul contiennent 0,1% de BSA. |
Informations générales
METTL14, is also named as Methyltransferase-like protein 14 or KIAA1627, is a 456 amino acid protein, which belongs to the MT-A70-like family and localized in the nucleus. The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues of some mRNAs and regulates the circadian clock and differentiation of embryonic stem cells. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing, processing and mRNA stability. M6A regulates the length of the circadian clock: acts as a early pace-setter in the circadian loop. M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naïve pluripotency-promoting transcripts results in transcript destabilization.