Anticorps Monoclonal anti-MGP

• Phare
• Validé par KD/KO

MGP Monoclonal Antibody for WB, IHC, IF-P, Indirect ELISA

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain, souris

Applications

WB, IHC, IF-P, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

1A1C3

N° de cat : 60055-1-PBS

Synonymes

GIG36, 1A1C3, Cell growth-inhibiting gene 36 protein, matrix Gla protein, MGLAP

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Galerie de données de validation

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  WB analysis using 60055-1-Ig (same clone as 60055-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 60055-1-Ig (MGP antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

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  WB analysis of human saliva using 60055-1-Ig (same clone as 60055-1-PBS)

  human saliva were subjected to SDS PAGE followed by western blot with 60055-1-Ig (MGP antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

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  WB analysis of human liver cancer using 60055-1-Ig (same clone as 60055-1-PBS)

  human liver cancer tissue were subjected to SDS PAGE followed by western blot with 60055-1-Ig (MGP antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

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  WB analysis of human brain using 60055-1-Ig (same clone as 60055-1-PBS)

  human brain tissue were subjected to SDS PAGE followed by western blot with 60055-1-Ig (MGP antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

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  WB analysis of human kidney using 60055-1-Ig (same clone as 60055-1-PBS)

  human kidney tissue were subjected to SDS PAGE followed by western blot with 60055-1-Ig (MGP antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

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  IHC staining of human colon cancer using 60055-1-Ig (same clone as 60055-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 60055-1-Ig (MGP antibody) at dilution of 1:800 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

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  IHC staining of human gliomas using 60055-1-Ig (same clone as 60055-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human gliomas tissue slide using 60055-1-Ig (MGP Antibody) at dilution of 1:800 (under 10x lens). This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

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  IHC staining of human gliomas using 60055-1-Ig (same clone as 60055-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human gliomas tissue slide using 60055-1-Ig (MGP Antibody) at dilution of 1:800 (under 40x lens). This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

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  IHC staining of human heart using 60055-1-Ig (same clone as 60055-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human heart tissue slide using 60055-1-Ig (MGP Antibody) at dilution of 1:800 (under 10x lens). This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

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  IHC staining of human heart using 60055-1-Ig (same clone as 60055-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human heart tissue slide using 60055-1-Ig (MGP Antibody) at dilution of 1:800 (under 40x lens). This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

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  IHC staining of human kidney using 60055-1-Ig (same clone as 60055-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 60055-1-Ig (MGP Antibody) at dilution of 1:800 (under 10x lens). This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human kidney using 60055-1-Ig (same clone as 60055-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 60055-1-Ig (MGP Antibody) at dilution of 1:800 (under 40x lens). This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human brain using 60055-1-Ig (same clone as 60055-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human brain using 60055-1-Ig(MGP antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human brain using 60055-1-Ig (same clone as 60055-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human brain using 60055-1-Ig(MGP antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human gliomas using 60055-1-Ig (same clone as 60055-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human gliomas using 60055-1-Ig(MGP antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human gliomas using 60055-1-Ig (same clone as 60055-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human gliomas using 60055-1-Ig(MGP antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human lung using 60055-1-Ig (same clone as 60055-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human lung using 60055-1-Ig(MGP antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human lung using 60055-1-Ig (same clone as 60055-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human lung using 60055-1-Ig(MGP antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

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  IF Staining of mouse kidney using 60055-1-Ig (same clone as 60055-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed mouse kidney tissue using MGP antibody (60055-1-Ig, Clone: 1A1C3 ) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 60055-1-Ig

  Biolayer interferometry (BLl) kinetic assays of 60055-1-Ig against Human MGP were performed. The Affinity Constant is 5.42 nM.

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Informations sur le produit

60055-1-PBS cible MGP dans les applications de WB, IHC, IF-P, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Mouse / IgG2a
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: MGP Protéine recombinante Ag1091
• Nom complet: matrix Gla protein
• Masse moléculaire calculée: 103 aa, 13 kDa
• Poids moléculaire observé: 12 kDa
• Numéro d’acquisition GenBank: BC005272
• Symbole du gène: MGP
• Identification du gène (NCBI): 4256
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Matrix Gla protein (MGP) is is a vitamin K-dependent, extracellular matrix protein. MGP plays a pivotal role in preventing soft tissue calcification and local mineralization of the vascular wall. Vitamin K deficiency leads to inactive uncarboxylated MGP (ucMGP), which accumulates at sites of arterial calcification. However MGP is synthesized in many tissues and is especially enriched in embryonic tissues and in cancer cells. Defects in MGP are the cause of Keutel syndrome (KS), which is an autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia.

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