Anticorps Recombinant de lapin anti-MICA/MICB

MICA/MICB Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

240735D5

N° de cat : 98110-1-PBS

Synonymes

MICB, MICA, 240735D5, MIC A, PERB11.1

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Galerie de données de validation

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  FC experiment of HeLa using 98110-1-RR (same clone as 98110-1-PBS)

  1x10^6 HeLa cells (left) or Jurkat cells (right) were surface stained with 0.25 ug Anti-Human MICA/MICB Rabbit Recombinant Antibody (98110-1-RR, Clone: 240735D5) and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (red), or 0.25 ug Isotype Control (blue). Cells were not fixed. This data was developed using the same antibody clone with 98110-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98110-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98110-1-RR against Human MICA were performed. The affinity constant is 0.907 nM.

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Informations sur le produit

98110-1-PBS cible MICA/MICB dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: MICA/MICB Protéine recombinante Eg1176
• Nom complet: MHC class I polypeptide-related sequence A
• Masse moléculaire calculée: 43 kDa
• Numéro d’acquisition GenBank: AAH16929.1
• Symbole du gène: MICA
• Identification du gène (NCBI): 4276
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

Human MHC class I chain-related genes located within the HLA class I region of chromosome 6 encode MHC class I chain-related A and B (MICA and MICB) (PMID: 11429322). MICA and MICB are stress-inducible surface molecules that are not associated with β2-microglobulin and do not present peptides (PMID: 9497295). They are expressed in intestinal epithelium and many epithelial tumors (PMID: 10359807). MICA and MICB are ligands for NKG2D which is an activating receptor that is expressed on most natural killer (NK) cells, CD8 αβ T cells, and γδ T cells (PMID: 10426993; 11491531). This antibody recognizes both MICA and MICB.

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