Anticorps Polyclonal de lapin anti-MICALL1

MICALL1 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 33503-1-PBS

Synonymes

KIAA1668, MICAL Like 1, MICAL-L1, MICAL-Like 1, MICAL-like protein 1

---

Galerie de données de validation

• 

  WB analysis using 33503-1-AP (same clone as 33503-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 33503-1-AP (MICALL1 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33503-1-PBS in a different storage buffer formulation.

---

Informations sur le produit

33503-1-PBS cible MICALL1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: MICALL1 Protéine recombinante Ag39169
• Nom complet: MICAL-like 1
• Masse moléculaire calculée: 93kDa，863aa
• Poids moléculaire observé: 125 kDa
• Numéro d’acquisition GenBank: NM_033386.3
• Symbole du gène: MICALL1
• Identification du gène (NCBI): 85377
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

MICALL1 (MICAL-like protein 1) is a protein involved in the regulation of cytoskeleton dynamics and is a member of the MICAL family. This protein interacts with other molecules through its N-terminal CH domain and C-terminal coiled-coil domain, primarily regulating the stability of microtubules and actin, thereby affecting processes such as cell shape, migration, and intracellular transport. Studies have shown that MICALL1 plays a key role in neuronal axon guidance, angiogenesis, and the establishment of epithelial cell polarity. Additionally, it binds to Rab GTPases (such as Rab8a) and is involved in vesicle transport and membrane remodeling. Aberrant expression of MICALL1 is associated with tumor metastasis and neurological diseases, with its molecular mechanisms involving precise regulation of cytoskeleton rearrangement, making it a potential therapeutic target.

{{ptg:RelatedPrimaryAntibodies}}