Anticorps Monoclonal anti-MIST1

MIST1 Monoclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain, porc, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

1E10B3

N° de cat : 68092-1-PBS

Synonymes

BHLHA15, MIST 1, MIST1

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Galerie de données de validation

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  WB analysis using 68092-1-Ig (same clone as 68092-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 68092-1-Ig (MIST1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68092-1-PBS in a different storage buffer formulation.

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Informations sur le produit

68092-1-PBS cible MIST1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, porc, rat, souris

• Réactivité: Humain, porc, rat, souris
• Hôte / Isotype: Mouse / IgG2a
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: MIST1 Protéine recombinante Ag18509
• Nom complet: basic helix-loop-helix family, member a15
• Masse moléculaire calculée: 189 aa, 21 kDa
• Poids moléculaire observé: 27 kDa
• Numéro d’acquisition GenBank: BC113394
• Symbole du gène: MIST1
• Identification du gène (NCBI): 168620
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Muscle intestine stomach expression 1 (MIST1), also named bHLHa15, is a secretory cell transcription factor that belongs to the basic helix-loop-helix superfamily. MIST1 is mainly expressed in serous secreted cells and essential for the development and maturation of secretory cells. Secretory cells lacking MIST1 exhibit structural and functional defects, including alterations in cytoskeletal organization and cell polarity and improper cell-cell junction. In healthy pancreata, MIST1 facilitates cell-to-cell communication, promotes acinar cell polarity, controls Ca2+ flux, promotes unfolded protein response (UPR) homeostasis, aids in vesicle assembly, and is required for regulated exocytosis. MIST1 was downregulated in pancreatic cancer tissues compared with normal or adjacent pancreatic tissues and lower MIST1 expression in pancreatic cancer cell lines than normal acinar cells (BxPC-3, PANC-1, SW 1990) (PMID:29859299). MIST1 is downregulated in the development of gastric cancer and in gastric cancer cells compared with SW620 cells (PMID:34149921).

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