Anticorps Polyclonal de lapin anti-KMT2A

KMT2A Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IF, ChIP, ELISA

Conjugaison

Non conjugué

Publications(3)

N° de cat : 29278-1-AP

Synonymes

MLL, HTRX, HRX, FLJ11783, CXXC7

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Galerie de données de validation

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  WB analysis using 29278-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 29278-1-AP (MLL antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: cellules Jurkat, cellules K-562

Dilution recommandée

• Western Blot (WB): WB : 1:1000-1:4000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Applications publiées

• WB: See 2 publications below
• IF: See 1 publications below
• ChIP: See 1 publications below

Informations sur le produit

29278-1-AP cible KMT2A dans les applications de WB, IF, ChIP, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Réactivité citée: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: KMT2A Protéine recombinante Ag30468
• Nom complet: myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
• Masse moléculaire calculée: 432 kDa
• Poids moléculaire observé: 180 kDa
• Numéro d’acquisition GenBank: NM_001197104
• Symbole du gène: MLL
• Identification du gène (NCBI): 4297
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

KMT2A, also known as mixed-lineage leukemia (MLL), is a gene that encodes a lysine methyltransferase responsible for the transcriptional activation through lysine 4 of histone 3 (H3K4) methylation. KMT2A is expressed mainly in the nucleus and is ubiquitously present in various tissues, particularly in ovary, lymph node, endometrium, thyroid, and brain tissue. It plays a significant role in embryonic development, hematopoiesis, and neurodevelopment. Mutations in KMT2A have been associated with several pathological conditions.

Publications

Species	Application	Title
human	WB,ChIP	Nat Commun; KMT2A associates with PHF5A-PHF14-HMG20A-RAI1 subcomplex in pancreatic cancer stem cells and epigenetically regulates their characteristics; Authors - Mai Abdel Mouti
human	IF	J Inflamm (Lond); Histone H3 posttranslational modified enzymes defined neutrophil plasticity and their vulnerability to IL-10 in the course of the inflammation; Authors - Paweł Piatek
human	WB	Cancer Lett; PARP1 interacts with WDR5 to enhance target gene recognition and facilitate tumorigenesis; Authors - Yali Qin

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