Anticorps Polyclonal de lapin anti-KMT2A

KMT2A Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 29278-1-PBS

Synonymes

MLL, HTRX, HRX, FLJ11783, CXXC7

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Galerie de données de validation

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  WB analysis using 29278-1-AP (same clone as 29278-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 29278-1-AP (MLL antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29278-1-PBS in a different storage buffer formulation.

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Informations sur le produit

29278-1-PBS cible KMT2A dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: KMT2A Protéine recombinante Ag30468
• Nom complet: myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
• Masse moléculaire calculée: 432 kDa
• Poids moléculaire observé: 180 kDa
• Numéro d’acquisition GenBank: NM_001197104
• Symbole du gène: MLL
• Identification du gène (NCBI): 4297
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

KMT2A, also known as mixed-lineage leukemia (MLL), is a gene that encodes a lysine methyltransferase responsible for the transcriptional activation through lysine 4 of histone 3 (H3K4) methylation. KMT2A is expressed mainly in the nucleus and is ubiquitously present in various tissues, particularly in ovary, lymph node, endometrium, thyroid, and brain tissue. It plays a significant role in embryonic development, hematopoiesis, and neurodevelopment. Mutations in KMT2A have been associated with several pathological conditions.

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