Anticorps Monoclonal anti-MLXIP

MLXIP Monoclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Mouse / IgG2b

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

2E11A4

N° de cat : 68977-1-PBS

Synonymes

MLX interacting protein, MIR, KIAA0867, Class E basic helix-loop-helix protein 36, BHLHE36

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Galerie de données de validation

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  WB analysis using 68977-1-Ig (same clone as 68977-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 68977-1-Ig (MLXIP antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68977-1-PBS in a different storage buffer formulation.

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Informations sur le produit

68977-1-PBS cible MLXIP dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG2b
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: MLXIP Protéine recombinante Ag4519
• Nom complet: MLX interacting protein
• Masse moléculaire calculée: 919 aa, 100 kDa
• Poids moléculaire observé: 130 kDa
• Numéro d’acquisition GenBank: BC039704
• Symbole du gène: MLXIP
• Identification du gène (NCBI): 22877
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Mlx-interacting protein(MLXIP), after forming heterodimers with MLX, can bind to and then activate transcription from CACGTG E boxes. The N terminus of MLXIP acts as a CRM1-dependent nuclear export signal and contribute to the cytoplasmic localization of the complex, and as a binding site for 13 protein. the C terminus contains a cytoplasmic localization signal and mediates protein-protein interaction of MONDOA and MLX. The complex play a role in transcriptional activation of glycolytic target genes and glucose-responsive gene regulation. This antibody could recognize isoform1(~110kd) and isoform3(~69kd) of MLXIP. A prominent and specific MLXIP of approximately 130 kDa was detected. It demonstrates that MLXIP associated specifically with Mlx in the cytoplasm (PMID: 11073985).

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