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Anticorps Polyclonal de lapin anti-MMP24

MMP24 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 30102-1-PBS

Synonymes

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using MMP24 Polyclonal antibody (30102-1-AP)

    WB analysis using 30102-1-AP (same clone as 30102-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30102-1-AP (MMP24 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30102-1-PBS in a different storage buffer formulation.

Informations sur le produit

30102-1-PBS cible MMP24 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

Réactivité Humain, rat, souris
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène MMP24 Protéine recombinante Ag31597
Nom complet matrix metallopeptidase 24 (membrane-inserted)
Masse moléculaire calculée73KD
Poids moléculaire observé55-58 kDa
Numéro d’acquisition GenBankNM_006690
Symbole du gène MMP24
Identification du gène (NCBI) 10893
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue remodeling, and disease processes, such as arthritis or metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP24 (MT5-MMP) is a membrane type matrix metalloproteinase attached to the cell membrane by a transmembrane domain (PMID: 30654475). MMP24 is mainly expressed in the nervous system, hippocampus, and cerebellum (PMID: 10727639,35177031). MMP24 may negatively regulate the aggressiveness of cancer cells under the stiff ECM environment during tumor progression (PMID: 32093160). MMP24 can be detected as 62-65 kDa and 55-58 kDa (PMID: 16495457,20942921,10622708).

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