Anticorps Recombinant de lapin anti-CD206

CD206 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

240344D12

N° de cat : 98031-1-PBS

Synonymes

Mrc1, MR, MMR, mannose receptor, C type 1, 240344D12

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Galerie de données de validation

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  FC experiment of mouse peritoneal macrophages using 98031-1-RR (same clone as 98031-1-PBS)

  1x10^6 mouse peritoneal macrophages were surface stained with 0.25 ug Anti-Mouse MMR/CD206 Rabbit Recombinant Antibody (98031-1-RR, Clone: 240344D12) or Isotype Control and PE-conjugated Goat Anti-Rabbit IgG. Cells were then stained with APC Anti-Mouse CD107b / LAMP2. Cells were not fixed. This data was developed using the same antibody clone with 98031-1-PBS in a different storage buffer formulation.

• 

  FC experiment of mouse peritoneal macrophages using 98031-1-RR (same clone as 98031-1-PBS)

  1x10^6 mouse peritoneal macrophages were surface stained with 0.25 ug Anti-Mouse MMR/CD206 Rabbit Recombinant Antibody (98031-1-RR, Clone: 240344D12) (red) or Isotype Control (blue) and PE-conjugated Goat Anti-Rabbit IgG. Cells were not fixed. This data was developed using the same antibody clone with 98031-1-PBS in a different storage buffer formulation.

• 

  Affinity and Kinetic Characterization of 98031-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98031-1-RR against Mouse CD206 were performed. The affinity constant is 75.8 nM.

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Informations sur le produit

98031-1-PBS cible CD206 dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: mannose receptor, C type 1
• Masse moléculaire calculée: 165 kDa
• Numéro d’acquisition GenBank: NM_008625.2
• Symbole du gène: CD206
• Identification du gène (NCBI): 17533
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

CD206, also named as MMR, CLEC13D and MRC1, is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. CD206 has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. CD206 is a 170 kDa transmembrane protein which contains 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail. It is expressed on most tissue macrophages, in vitro derived dendritic cells, lymphatic and sinusoidal endothelia.

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