Anticorps Recombinant de lapin anti-MOG

MOG Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, porc, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

250235E1

N° de cat : 83063-6-PBS

Synonymes

MOGIG 2, Myelin-oligodendrocyte glycoprotein

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Galerie de données de validation

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  WB analysis using 83063-6-RR (same clone as 83063-6-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 83063-6-RR (MOG antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83063-6-PBS in a different storage buffer formulation.

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Informations sur le produit

83063-6-PBS cible MOG dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, porc, rat, souris

• Réactivité: Humain, porc, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: MOG Protéine recombinante Eg2878
• Nom complet: myelin oligodendrocyte glycoprotein
• Masse moléculaire calculée: 24 kDa
• Poids moléculaire observé: 25-28 kDa
• Numéro d’acquisition GenBank: N/A
• Symbole du gène: MOG
• Identification du gène (NCBI): 4340
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Myelin/oligodendrocyte glycoprotein (MOG), a 23~28 kDa glycoprotein, a myelin antigen at the outer surface of the central nervous system (CNS) myelin sheath, which may trigger T-cell as well as B-cell responses. It therefore constitutes a pivotal target for autoimmune responses, which result in inflammation and also demyelination in the CNS. Its presence on the outer- most lamellae of mature CNS myelin and its late appearance during myelinogenesis suggest that it contributes to myelin maturation or maintenance. 10 isoforms of MOG produced by alternative splicing have been described, and heterodimers may be formed between the different isoforms. Defects in MOG are the cause of narcolepsy type 7 (NRCLP7), a neurological disabling sleep disorder characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Role of MOG in the pathogenesis of multiple sclerosis (MS) has been reported but remains to be clarified.

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