Anticorps Recombinant de lapin anti-MPP8

MPP8 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

242205B5

N° de cat : 84719-4-PBS

Synonymes

MPHOSPH8, 242205B5, HSMPP8, M-phase phosphoprotein 8, Twa3

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Galerie de données de validation

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  WB analysis using 84719-4-RR (same clone as 84719-4-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84719-4-RR (MPP8 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84719-4-PBS in a different storage buffer formulation.

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Informations sur le produit

84719-4-PBS cible MPP8 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: MPP8 Protéine recombinante Ag10268
• Nom complet: M-phase phosphoprotein 8
• Masse moléculaire calculée: 860 aa, 97 kDa
• Poids moléculaire observé: 97-105 kDa
• Numéro d’acquisition GenBank: BC003542
• Symbole du gène: MPP8
• Identification du gène (NCBI): 54737
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

The M-phase phosphoprotein 8 (MPP8) was firstly identified to coimmunoprecipitate with the RanBPM-comprised large protein complex [PMID:19956676]. It also binds to methylated H3K9 and recruited the H3K9 methyltransferases GLP and ESET, as well as DNA methyltransferase 3A (DNMT3A) to the promoter of the E-cadherin gene, a key regulator of tumor cell growth and epithelial-to-mesenchymal transition (EMT) [PMID:18726070]. This binding event of MPP8-H3K9me modulates the expression of E-cadherin, a key regulator of cell-cell adhesion with implications in embryonic development, tissue morphogenesis and homeostasis , together with H3K9 methyltransferases GLP and ESET and DNA methyltransferase 3a (Dnmt3a)

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