Anticorps Polyclonal de lapin anti-MPZL2

• Phare
• Validé par KD/KO

MPZL2 Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IHC, IF, ELISA

Conjugaison

Non conjugué

Publications(10)

N° de cat : 11787-1-AP

Synonymes

Epithelial V like antigen 1, EVA, EVA1, MPZL2, myelin protein zero like 2

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Galerie de données de validation

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  WB analysis using 11787-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 11787-1-AP (MPZL2 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: cellules A431, cellules HaCaT

Dilution recommandée

• Western Blot (WB): WB : 1:1000-1:4000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Applications publiées

• KD/KO: See 2 publications below
• WB: See 4 publications below
• IHC: See 4 publications below
• IF: See 3 publications below
• FC: See 1 publications below

Informations sur le produit

11787-1-AP cible MPZL2 dans les applications de WB, IHC, IF, ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Réactivité citée: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: MPZL2 Protéine recombinante Ag2419
• Nom complet: myelin protein zero-like 2
• Masse moléculaire calculée: 215 aa, 24 kDa
• Poids moléculaire observé: 24-30 kDa
• Numéro d’acquisition GenBank: BC017774
• Symbole du gène: MPZL2
• Identification du gène (NCBI): 10205
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

MPZL2 (myelin protein zero-like 2), also named as EVA (epithelial V-like antigen) or EVA1, is a type 1 transmembrane protein of the myelin P0 protein family, containing an Ig-like V-type (immunoglobulin-like) domain and two potential glycosylation sites. MPZL2 is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis.

Publications

Species	Application	Title
mouse	WB	Cell; Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human.; Authors - Wu Jun J
mouse	IF	Am J Hum Genet; Hearing restoration by gene replacement therapy for a multisite-expressed gene in a mouse model of human DFNB111 deafness; Authors - Luoying Jiang ; KD Validated
mouse	IF	Am J Hum Genet; MPZL2, Encoding the Epithelial Junctional Protein Myelin Protein Zero-like 2, Is Essential for Hearing in Man and Mouse.; Authors - Mieke Wesdorp
human	WB	PLoS Pathog; Haploid Genetic Screens Identify an Essential Role for PLP2 in the Downregulation of Novel Plasma Membrane Targets by Viral E3 Ubiquitin Ligases.; Authors - Timms Richard T RT
human	WB,IHC	Cancer Sci; Epithelial V-like antigen 1 promotes hepatocellular carcinoma growth and metastasis via the ERBB-PI3K-AKT pathway.; Authors - QianZhi Ni ; KD Validated
mouse	WB,IF	Hum Genet; MPZL2 is a novel gene associated with autosomal recessive nonsyndromic moderate hearing loss.; Authors - Guney Bademci

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