Anticorps Recombinant de lapin anti-MRC2

MRC2 Recombinant Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

250494D5

N° de cat : 86028-1-PBS

Synonymes

C type mannose receptor 2, CD280, CLEC13E, C-type lectin domain family 13 member E, C-type mannose receptor 2

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Galerie de données de validation

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  WB analysis using 86028-1-RR (same clone as 86028-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 86028-1-RR (MRC2 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86028-1-PBS in a different storage buffer formulation.

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  IHC staining of human tonsillitis using 86028-1-RR (same clone as 86028-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 86028-1-RR (MRC2 antibody) at dilution of 1:800 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 86028-1-PBS in a different storage buffer formulation.

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  IHC staining of human tonsillitis using 86028-1-RR (same clone as 86028-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 86028-1-RR (MRC2 antibody) at dilution of 1:800 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 86028-1-PBS in a different storage buffer formulation.

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Informations sur le produit

86028-1-PBS cible MRC2 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: MRC2 Protéine recombinante Eg2653
• Nom complet: mannose receptor, C type 2
• Masse moléculaire calculée: 167 kDa
• Poids moléculaire observé: 180 kDa
• Numéro d’acquisition GenBank: NM_006039.5
• Symbole du gène: MRC2
• Identification du gène (NCBI): 9902
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

C-type mannose receptor 2 (MRC2), also known as CD280, CLEC13E, ENDO180, KIAA0709, or UPARAP, is a type I transmembrane glycoprotein that belongs to the macrophage mannose receptor protein family (PMID: 10683150; 10636902; 9734811). It contains an N-terminal cysteine-rich domain, a fibronectin type II domain (FNII), eight C-type-lectin-like domains, and a transmembrane region followed by a small cytoplasmic domain (PMID: 34012764). MRC2 is a recycling endocytic receptor that functions in both these cellular activities by promoting cell migration and uptake of collagens for intracellular degradation (PMID: 17974964). MRC2 is expressed in several cells and organs including fibroblasts, endothelial cells, and macrophages. Altered MRC2 expression has been associated with the development and progression of different cancers, including head and neck squamous cell carcinoma, breast cancer, hepatocellular cancer, and prostate cancer (PMID: 36188226; 37666484; 17974964; 25162823).

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