Anticorps Monoclonal anti-MRE11A

MRE11A Monoclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

1B12B2

N° de cat : 67570-1-PBS

Synonymes

MRE11, 1B12B2, ATLD, Double-strand break repair protein MRE11, EC:3.1.-.-

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Galerie de données de validation

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  WB analysis using 67570-1-Ig (same clone as 67570-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67570-1-Ig (MRE11A antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67570-1-PBS in a different storage buffer formulation.

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Informations sur le produit

67570-1-PBS cible MRE11A dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: MRE11A Protéine recombinante Ag28847
• Nom complet: MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
• Poids moléculaire observé: 81 kDa
• Numéro d’acquisition GenBank: BC063458
• Symbole du gène: MRE11A
• Identification du gène (NCBI): 4361
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine G
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Mre11 (meiotic recombination 11), also named as Mre11A, is a component of the MRN( MRE11/RAD50/NBS1) complex which is a versatile complex, playing a key role in the sensing, processing, and repair of DSBs. MRE11 possesses both endonuclease and 3'-5' exonuclease activity. It contains two DNA-binding domains (DBDs), enabling it to bind both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). After DSBs, MRE11 is loaded onto DSBs sites and cleaves DNA by cooperating with CtIP (CtBP [C terminal binding protein] interacting protein) to initiate end resection. It's reported that MRE11 is over-expressed in breast cancers. (PMID:38128537; 22914783)

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