Anticorps Monoclonal anti-MRP1

MRP1 Monoclonal Antibody for WB, IF/ICC, ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain

Applications

WB, IF/ICC, ELISA

Conjugaison

Non conjugué

CloneNo.

1G4A2

N° de cat : 67228-1-PBS

Synonymes

ABCC1, 1G4A2, MRP1/ABCC1

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Galerie de données de validation

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  WB analysis using 67228-1-Ig (same clone as 67228-1-PBS)

  Non-boil and boiled HepG2 and A549 cell lysates were subjected to SDS PAGE followed by western blot with 67228-1-Ig (ABCC1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. Left panel was exposed for 20 sec. and right panel was exposed for 1 min. This data was developed using the same antibody clone with 67228-1-PBS in a different storage buffer formulation.

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  IF Staining of A549 using 67228-1-Ig (same clone as 67228-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed A549 cells using MRP1 antibody (67228-1-Ig, Clone: 1G4A2 ) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 67228-1-PBS in a different storage buffer formulation.

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Informations sur le produit

67228-1-PBS cible MRP1 dans les applications de WB, IF/ICC, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: MRP1 Protéine recombinante Ag27048
• Nom complet: ATP-binding cassette, sub-family C (CFTR/MRP), member 1
• Masse moléculaire calculée: 172 kDa
• Poids moléculaire observé: 180-190 kDa
• Numéro d’acquisition GenBank: NM_004996
• Symbole du gène: MRP1
• Identification du gène (NCBI): 4363
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine G
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Multidrug resistant-associated protein 1 (MRP1; ABCC1) is a member of the ATP-binding cassette (ABC) transporter protein superfamily, subfamily C. MRP1 is overexpressed in cancers and contributes to the occurrence of multidrug resistance (MDR). Expression of MRP1 has been considered as a negative marker for the outcome of chemotherapy. Recently MRP1 has been reported to play a crucial role in Aβ clearance at the blood-brain barrier.

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