Anticorps Polyclonal de lapin anti-MRP2

MRP2 Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

Conjugaison

Non conjugué

N° de cat : 24893-1-PBS

Synonymes

ABCC2, ABCC 2, ATP-binding cassette sub-family C member 2, CMOAT, CMOAT1

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Galerie de données de validation

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  WB analysis of HepG2 using 24893-1-AP (same clone as 24893-1-PBS)

  HepG2 cells were subjected to SDS PAGE followed by western blot with 24893-1-AP (MRP2 antibody at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24893-1-PBS in a different storage buffer formulation.

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  IHC staining of human small intestine using 24893-1-AP (same clone as 24893-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human small intestine tissue slide using 24893-1-AP (MRP2 antibody at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 24893-1-PBS in a different storage buffer formulation.

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  IHC staining of human small intestine using 24893-1-AP (same clone as 24893-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human small intestine tissue slide using 24893-1-AP (MRP2 antibody at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 24893-1-PBS in a different storage buffer formulation.

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Informations sur le produit

24893-1-PBS cible MRP2 dans les applications de et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: MRP2 Protéine recombinante Ag18694
• Nom complet: ATP-binding cassette, sub-family C (CFTR/MRP), member 2
• Masse moléculaire calculée: 1545 aa, 174 kDa
• Poids moléculaire observé: 190-250 kDa
• Numéro d’acquisition GenBank: BC136419
• Symbole du gène: ABCC2
• Identification du gène (NCBI): 1244
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Multi-drug resistance protein 2 (MRP2), also known as ABCC2, is an ATP binding cassette (ABC) transporter responsible for biliary excretion of xenobiotics, endobiotics, and their metabolites. Deficiency in ABCC2 results in the clinical disorder Dubin-Johnson syndrome. MRP2 is found to be expressed in a variety of human cancers, and is associated with resistance of tumor cells to various anticancer drugs including cisplatin. The predicted molecular weight of MRP2 is 174 kDa, while mature MRP2 usually has a slower migration around 190-250 kDa due to the glycosylation. (16434545, 18834541, 23045960)

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