Anticorps Recombinant de lapin anti-MSRA

MSRA Recombinant Antibody for WB, IF/ICC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat

Applications

WB, IF/ICC, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

251025H2

N° de cat : 86358-1-PBS

Synonymes

EC:1.8.4.11, Mitochondrial peptide methionine sulfoxide reductase, Peptide Met(O) reductase, Peptide-methionine, PMSR

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Galerie de données de validation

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  WB analysis using 86358-1-RR (same clone as 86358-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 86358-1-RR (MSRA antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86358-1-PBS in a different storage buffer formulation.

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  IF Staining of THP-1 using 86358-1-RR (same clone as 86358-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed THP-1 cells using MSRA antibody (86358-1-RR, Clone: 251025H2 ) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 86358-1-PBS in a different storage buffer formulation.

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Informations sur le produit

86358-1-PBS cible MSRA dans les applications de WB, IF/ICC, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat

• Réactivité: Humain, rat
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: MSRA Protéine recombinante Ag6053
• Nom complet: methionine sulfoxide reductase A
• Masse moléculaire calculée: 26 kDa
• Poids moléculaire observé: 24-26 kDa
• Numéro d’acquisition GenBank: BC054033
• Symbole du gène: MSRA
• Identification du gène (NCBI): 4482
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Methionine sulfoxide reductase A (MSRA) is an antioxidant enzyme found in all domains of life that catalyzes the reduction of methionine-S-sulfoxide (MSO) to methionine in proteins and free amino acids (PMID: 28874471). MSRA has some isoforms with MW of 19~26 kDa. MSRA functions in the repair of oxidatively damaged proteins to restore biological activity. Transfection of MSRA reduced colony formation and the invasiveness of HCC cell lines. Studies have demonstrated the downregulation of MSRA in multiple human tumors, including breast cancers and its levels have been linked to advanced tumor grades (PMID: 20937881).

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