Anticorps Monoclonal anti-MTMR2

• Phare
• Validé par KD/KO

MTMR2 Monoclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Mouse / IgG2b

Réactivité testée

Humain, porc

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

1B11B7

N° de cat : 67312-1-PBS

Synonymes

CMT4B, CMT4B1, KIAA1073, MTMR2, myotubularin related protein 2

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Galerie de données de validation

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  WB analysis of HeLa using 67312-1-Ig (same clone as 67312-1-PBS)

  HeLa cells were subjected to SDS PAGE followed by western blot with 67312-1-Ig (MTMR2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67312-1-PBS in a different storage buffer formulation.

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  WB analysis of HeLa using 67312-1-Ig (same clone as 67312-1-PBS)

  WB result of MTMR2 antibody (67312-1-Ig; 1:2000; incubated at room temperature for 1.5 hours) with sh-Control and sh-MTMR2 transfected HeLa cells. This data was developed using the same antibody clone with 67312-1-PBS in a different storage buffer formulation.

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  WB analysis of HEK-293 using 67312-1-Ig (same clone as 67312-1-PBS)

  HEK-293 cells were subjected to SDS PAGE followed by western blot with 67312-1-Ig (MTMR2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67312-1-PBS in a different storage buffer formulation.

• 

  WB analysis of Jurkat using 67312-1-Ig (same clone as 67312-1-PBS)

  Jurkat cells were subjected to SDS PAGE followed by western blot with 67312-1-Ig (MTMR2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67312-1-PBS in a different storage buffer formulation.

• 

  WB analysis of pig brain using 67312-1-Ig (same clone as 67312-1-PBS)

  pig brain tissue were subjected to SDS PAGE followed by western blot with 67312-1-Ig (MTMR2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67312-1-PBS in a different storage buffer formulation.

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Informations sur le produit

67312-1-PBS cible MTMR2 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, porc

• Réactivité: Humain, porc
• Hôte / Isotype: Mouse / IgG2b
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: MTMR2 Protéine recombinante Ag28413
• Nom complet: myotubularin related protein 2
• Masse moléculaire calculée: 73 kDa
• Poids moléculaire observé: 66-73 kDa
• Numéro d’acquisition GenBank: BC052990
• Symbole du gène: MTMR2
• Identification du gène (NCBI): 8898
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

MTMR2(myotubularin-related protein 2) is also named as KIAA1073 and belongs to the non-receptor class myotubularin subfamily, which is characterized by the presence of a phosphatase domain. It may regulate vesicular trafficking in Schwann cells (PMID:17880751) and its reversible phosphorylation represents a critical mechanism for regulating the subcellular localization of MTMR2(PMID:21372139). MTMR2 is a 73 kDa protein in its monomeric form and exist as a dimer within cells and the protein re-localizes to membranes in hypo-osmotic settings(PMID:16399794). Defects in MTMR2 are the cause of Charcot-Marie-Tooth disease type 4B1 (CMT4B1). MTMR2 has two isofroms with the molecular mass of 73 and 66 kDa.

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