Anticorps Polyclonal de lapin anti-MTUS1

MTUS1 Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, ELISA

Conjugaison

Non conjugué

N° de cat : 18791-1-AP

Synonymes

AT2 receptor binding protein, ATBP, ATIP, GK1, KIAA1288, MP44, MTSG1, MTUS1

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Galerie de données de validation

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  WB analysis of human skeletal muscle using 18791-1-AP

  human skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 18791-1-AP (MTUS1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

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  WB analysis of mouse uterus using 18791-1-AP

  mouse uterus tissue were subjected to SDS PAGE followed by western blot with 18791-1-AP (MTUS1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

• 

  WB analysis of human skeletal muscle using 18791-1-AP

  human skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 18791-1-AP (MTUS1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: tissu de muscle squelettique humain, tissu utérin de souris

Dilution recommandée

• Western Blot (WB): WB : 1:500-1:2000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Informations sur le produit

18791-1-AP cible MTUS1 dans les applications de WB, ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: MTUS1 Protéine recombinante Ag5605
• Nom complet: mitochondrial tumor suppressor 1
• Masse moléculaire calculée: 51 kDa, 141 kDa
• Poids moléculaire observé: 120 kDa, 180 kDa
• Numéro d’acquisition GenBank: BC033842
• Symbole du gène: MTUS1
• Identification du gène (NCBI): 57509
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

MTUS1, also named as ATBP, ATIP, GK1, KIAA1288 and MTSG1, Belongs to the MTUS1 family. It cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. MTUS1 may be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. MTUS1 up-regulation during cellular transition from proliferation to quiescence and differentiation. It is a potential tumor suppressor gene located at chromosome 8p21.3.22, near marker D8S254. According to the functional data and intracellular localization, MTUS1 also named as mitochondrial tumor suppressor gene 1 (MTSG1). One main feature common to all ATIP members is the presence of a large C-terminal coiled-coil domain that allows homo- and hetero-dimerization of these proteins. (PMID:12692079, 15123706) The antibody can recognize all the isoforms except isoform 5 (85-90kd). The antibody tested HomoDimer isoforms (110-120/180kd) in Human skeletal muscle.