Anticorps Recombinant de lapin anti-MTUS1

MTUS1 Recombinant Antibody for WB, IF/ICC, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, IF/ICC, ELISA

Conjugaison

Non conjugué

CloneNo.

242537B7

N° de cat : 85117-4-RR

Synonymes

ATIP, ATBP, AT2 receptor-binding protein, AT2 receptor binding protein, Angiotensin-II type 2 receptor-interacting protein

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Galerie de données de validation

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  WB analysis using 85117-4-RR

  Various lysates were subjected to SDS PAGE followed by western blot with 85117-4-RR (MTUS1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

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  IF Staining of PC-3 using 85117-4-RR

  Immunofluorescent analysis of (4% PFA) fixed PC-3 cells using MTUS1 antibody (85117-4-RR, Clone: 242537B7 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red).

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Applications testées

• Résultats positifs en WB: cellules A549, cellules HepG2, cellules SKOV-3, tissu cérébral de souris
• Résultats positifs en IF/ICC: cellules PC-3,

Dilution recommandée

• Western Blot (WB): WB : 1:1000-1:4000
• Immunofluorescence (IF)/ICC: IF/ICC : 1:200-1:800

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Informations sur le produit

85117-4-RR cible MTUS1 dans les applications de WB, IF/ICC, ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: MTUS1 Protéine recombinante Ag4242
• Nom complet: mitochondrial tumor suppressor 1
• Masse moléculaire calculée: 51 kDa, 141 kDa
• Poids moléculaire observé: 50 kDa
• Numéro d’acquisition GenBank: BC033842
• Symbole du gène: MTUS1
• Identification du gène (NCBI): 57509
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

MTUS1, also named as ATBP, ATIP, GK1, KIAA1288 and MTSG1, Belongs to the MTUS1 family. It cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. MTUS1 may be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. MTUS1 up-regulation during cellular transition from proliferation to quiescence and differentiation. It is a potential tumor suppressor gene located at chromosome 8p21.3.22, near marker D8S254. According to the functional data and intracellular localization, MTUS1 also named as mitochondrial tumor suppressor gene 1 (MTSG1). One main feature common to all ATIP members is the presence of a large C-terminal coiled-coil domain that allows homo- and hetero-dimerization of these proteins. (PMID:12692079, 15123706).

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