Anticorps Polyclonal de lapin anti-MXRA5

• Phare
• Validé par KD/KO

MXRA5 Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 25472-1-PBS

Synonymes

Adlican

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Galerie de données de validation

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  WB analysis using 25472-1-AP (same clone as 25472-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 25472-1-AP (MXRA5 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 25472-1-PBS in a different storage buffer formulation.

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  IHC staining of human kidney using 25472-1-AP (same clone as 25472-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 25472-1-AP (MXRA5 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25472-1-PBS in a different storage buffer formulation.

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  IHC staining of human colon cancer using 25472-1-AP (same clone as 25472-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 25472-1-AP (MXRA5 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25472-1-PBS in a different storage buffer formulation.

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  IHC staining of human colon cancer using 25472-1-AP (same clone as 25472-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 25472-1-AP (MXRA5 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25472-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human kidney using 25472-1-AP (same clone as 25472-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 25472-1-AP (MXRA5 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25472-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human liver using 25472-1-AP (same clone as 25472-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 25472-1-AP (MXRA5 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25472-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human liver using 25472-1-AP (same clone as 25472-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 25472-1-AP (MXRA5 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25472-1-PBS in a different storage buffer formulation.

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Informations sur le produit

25472-1-PBS cible MXRA5 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: matrix-remodelling associated 5
• Masse moléculaire calculée: 312 kDa
• Poids moléculaire observé: 163 kDa, 312 kDa
• Numéro d’acquisition GenBank: NM_015419
• Symbole du gène: MXRA5
• Identification du gène (NCBI): 25878
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

MXRA5, or adlican, is an adhesion proteoglycan involved in extracellular matrix (ECM) remodeling and cell-cell adhesion (PMID: 22696596). In kidney, MXRA5 has anti-inflammatory and anti-fibrotic properties by limiting the induction of chemokines, fibronectin and collagen expression in response to TGB1 and pro-inflammatory stimuli (PMID: 27599751). MXRA5 was identified as a novel biomarker in colorectal cancer, mainly located in the cytoplasm of CRC cells (PMID:23420087). Exome sequencing identified MXRA5 as a novel cancer gene mutated in non-small cell lung carcinoma (PMID: 22696596). MXRA5 was detected 163 kDa in human proximal tubular cells (PMID:27599751).

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