Anticorps Recombinant de lapin anti-Mesothelin

Mesothelin Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

243099D4

N° de cat : 85774-4-PBS

Synonymes

Megakaryocyte-potentiating factor, Mes, Mesothelin, cleaved form, Mpf, Msln

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Galerie de données de validation

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  WB analysis of mouse serum using 85774-4-RR (same clone as 85774-4-PBS)

  mouse serum were subjected to SDS PAGE followed by western blot with 85774-4-RR (Msln antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85774-4-PBS in a different storage buffer formulation.

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Informations sur le produit

85774-4-PBS cible Mesothelin dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Mesothelin Protéine recombinante Eg2864
• Nom complet: mesothelin
• Masse moléculaire calculée: 69 kDa
• Poids moléculaire observé: 46 kDa
• Numéro d’acquisition GenBank: NM_018857.1
• Symbole du gène: Msln
• Identification du gène (NCBI): 56047
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Mesothelin (MSLN) is a cell surface glycoprotein that was discovered in 1992 by Kai Chang, Ira Pastan, and Mark Willingham at the National Cancer Institute in Bethesda, MD. It is synthesized as a 69-kDa precursor protein, which is cleaved to form two proteins: a membrane-bound MSLN and a soluble megakaryocyte potentiating factor (MPF). MSLN is overexpressed in various tumor types, including mesothelioma, ovarian cancer, pancreatic adenocarcinoma, gastric cancer, and triple-negative breast cancer (TNBC). However, it is expressed at low levels in normal tissues, primarily on the mesothelial cells lining the pleura, pericardium, and peritoneum. (PMID: 37869242)

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