Anticorps Polyclonal de lapin anti-Mrgprx1

Mrgprx1 Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

rat, souris

Applications

Conjugaison

Non conjugué

N° de cat : 33332-1-AP

Synonymes

Mas-related G-protein coupled receptor member C11, Mas-related G-protein coupled receptor member X1, Mrgc11, Mrgprc11, Sensory neuron-specific G-protein coupled receptor 1

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Galerie de données de validation

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  WB analysis using 33332-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 33332-1-AP (Mrgprx1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: tissu hépatique de souris, tissu cardiaque de rat

Dilution recommandée

• Western Blot (WB): WB : 1:500-1:2000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Informations sur le produit

33332-1-AP cible Mrgprx1 dans les applications de et montre une réactivité avec des échantillons rat, souris

• Réactivité: rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: MAS-related GPR, member X1
• Masse moléculaire calculée: 322aa, 37 kDa
• Poids moléculaire observé: 35 kDa
• Numéro d’acquisition GenBank: NM_207540
• Symbole du gène: Mrgprx1
• Identification du gène (NCBI): 404242
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

MRGPRX1 is a MAS-related G protein-coupled receptor (GPCR) primarily expressed in dorsal root ganglion (DRG) neurons and is a key receptor for itch perception. It can be activated by various endogenous peptides and exogenous ligands, triggering itch and pain signals through Gi and Gq signaling pathways. The activation of MRGPRX1 not only induces the sensation of itch in peripheral neurons but also inhibits neurotransmitter release in the spinal cord via the Gi1 pathway, alleviating chronic pain. Additionally, the structure and activation mechanism of MRGPRX1 have been elucidated, with its unique ligand-binding pocket and activation process providing a theoretical basis for the development of novel analgesic and antipruritic drugs.

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