Anticorps Monoclonal anti-Myocilin

Myocilin Monoclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain, porc, rat, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

4B1F6

N° de cat : 60357-1-PBS

Synonymes

GLC1A, GPOA, JOAG, JOAG1, MYOC, myocilin, TIGR

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Galerie de données de validation

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  WB analysis of pig heart using 60357-1-Ig (same clone as 60357-1-PBS)

  pig heart tissue were subjected to SDS PAGE followed by western blot with 60357-1-Ig (Myocilin antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60357-1-PBS in a different storage buffer formulation.

• 

  WB analysis of rat heart using 60357-1-Ig (same clone as 60357-1-PBS)

  rat heart tissue were subjected to SDS PAGE followed by western blot with 60357-1-Ig (Myocilin antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60357-1-PBS in a different storage buffer formulation.

• 

  WB analysis of human skeletal muscle using 60357-1-Ig (same clone as 60357-1-PBS)

  human skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 60357-1-Ig (Myocilin antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60357-1-PBS in a different storage buffer formulation.

• 

  WB analysis of human spleen using 60357-1-Ig (same clone as 60357-1-PBS)

  human spleen tissue were subjected to SDS PAGE followed by western blot with 60357-1-Ig (Myocilin antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60357-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human heart using 60357-1-Ig (same clone as 60357-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human heart tissue slide using 60357-1-Ig (Myocilin antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 60357-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human heart using 60357-1-Ig (same clone as 60357-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human heart tissue slide using 60357-1-Ig (Myocilin antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 60357-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human skeletal muscle using 60357-1-Ig (same clone as 60357-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human skeletal muscle tissue slide using 60357-1-Ig (Myocilin antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 60357-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human skeletal muscle using 60357-1-Ig (same clone as 60357-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human skeletal muscle tissue slide using 60357-1-Ig (Myocilin antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 60357-1-PBS in a different storage buffer formulation.

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Informations sur le produit

60357-1-PBS cible Myocilin dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, porc, rat, souris

• Réactivité: Humain, porc, rat, souris
• Hôte / Isotype: Mouse / IgG2a
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: Myocilin Protéine recombinante Ag5492
• Nom complet: myocilin, trabecular meshwork inducible glucocorticoid response
• Masse moléculaire calculée: 57 kDa
• Poids moléculaire observé: 50-57 kDa
• Numéro d’acquisition GenBank: BC029261
• Symbole du gène: Myocilin
• Identification du gène (NCBI): 4653
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Myocilin (MYOC), also known as TIGR or GLC1A, is a secreted glycoprotein of the olfactomedin family, originally identified in trabecular meshwork cells after prolonged treatment with glucocorticoids, and, independently, in the retina (PMID: 9176893; 9169133). It may participate in the obstruction of fluid outflow in the trabecular meshwork. Defects in MYOC are the cause of primary open angle glaucoma (POAG) (PMID: 21709622).

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