Anticorps Recombinant de lapin anti-N-cadherin

N-cadherin Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

230259D7

N° de cat : 98006-1-PBS

Synonymes

N-cadherin/CD325, 230259D7, Cadherin 2, Cadherin-2, CD325

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Galerie de données de validation

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  FC experiment of HeLa using 98006-1-RR (same clone as 98006-1-PBS)

  1x10^6 HeLa cells (left) or MCF-7 cells (right) were surface stained with 0.25 ug Anti-Human N-cadherin/CD325 Rabbit Recombinant Antibody (98006-1-RR, Clone: 230259D7) and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (red), or 0.25 ug Isotype Control (blue). Cells were not fixed. This data was developed using the same antibody clone with 98006-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98006-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98006-1-RR against Human N-cadherin were performed. The affinity constant is 2.73 nM.

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Informations sur le produit

98006-1-PBS cible N-cadherin dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: N-cadherin Protéine recombinante Eg0701
• Nom complet: cadherin 2, type 1, N-cadherin (neuronal)
• Masse moléculaire calculée: 100 kDa
• Numéro d’acquisition GenBank: NM_001792.4
• Symbole du gène: N-cadherin
• Identification du gène (NCBI): 1000
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. Stable for one year after shipment.

Informations générales

Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. N-cadherin (neural cadherin), also known as CDH2 (cadherin 2), is a 130-kDa transmembrane protein and a classical member of the cadherin superfamily which also include E-, P-, R-, and B-cadherins. Expression of N-cadherin has been reported on various cell types including neurons, endothelial cells and cardiac myocytes (PMID: 11282032; 9508779; 8125202). N-cadherin has functions in early brain morphogenesis, synaptogenesis and synaptic plasticity (PMID: 23321619).

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