Anticorps Polyclonal de lapin anti-SLC4A7/NBCn1

SLC4A7/NBCn1 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 29442-1-PBS

Synonymes

NBCn1, SLC4A7, NBC2, NBC3

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Galerie de données de validation

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  WB analysis using 29442-1-AP (same clone as 29442-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 29442-1-AP (SLC4A7/NBCn1 antibody) at dilution of 1:2500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29442-1-PBS in a different storage buffer formulation.

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Informations sur le produit

29442-1-PBS cible SLC4A7/NBCn1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: SLC4A7/NBCn1 Protéine recombinante Ag30545
• Nom complet: solute carrier family 4, sodium bicarbonate cotransporter, member 7
• Masse moléculaire calculée: 136 kDa
• Poids moléculaire observé: 136 kDa
• Numéro d’acquisition GenBank: NM_003615
• Symbole du gène: NBCn1/SLC4A7
• Identification du gène (NCBI): 9497
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

SLC4A7 also known as NBCn1, NBC3, NBC2, is an electroneutral Na(+)/HCO(3)(-) cotransporter (PMID: 14736710). SLC4A7 mediates the coupled movement of sodium and bicarbonate ions across the plasma membrane. SLC4A7 plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis (PubMed:29779931). SLC4A7 is expressed in testis, spleen, and retina. SLC4A7 may be a major regulator of extracellular pH of retina where light stimulation produces an extracellular alkalization and may contribute as a solute transporter to the prevention of retinal detachment(PMID: 9610397).

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