Anticorps Recombinant de lapin anti-NCDN

NCDN Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

243146E2

N° de cat : 85730-1-PBS

Synonymes

Neurochondrin, KIAA0607, NEDIES

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Galerie de données de validation

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  WB analysis using 85730-1-RR (same clone as 85730-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85730-1-RR (NCDN antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85730-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 85730-1-RR

  Biolayer interferometry (BLl) kinetic assays of 85730-1-RR against Human NCDN were performed. The affinity constant is 1.35 nM.

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Informations sur le produit

85730-1-PBS cible NCDN dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: NCDN Protéine recombinante Ag3859
• Nom complet: neurochondrin
• Masse moléculaire calculée: 729 aa, 79 kDa
• Poids moléculaire observé: 75-79 kDa
• Numéro d’acquisition GenBank: BC024592
• Symbole du gène: Neurochondrin
• Identification du gène (NCBI): 23154
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

NCDN protein (Neurochondrin) is a highly conserved 79 kDa adaptor protein, which was first discovered in 1997 and mainly expressed in the nervous system. NCDN protein plays an important role in neuronal differentiation, formation and maintenance of dendritic spines. It is involved in the development of synapses, neuronal differentiation and signal transduction, and maintains cell polarity by regulating dendritic morphogenesis and neural signal pathway. Recent studies have found that NCDN protein is expressed not only in neurons, but also in myeloid cells (such as neutrophils), and plays a role as a negative regulator of innate immunity. Mice lacking NCDN in myeloid cells are more immune to bacterial infection because of the increased reactivity of neutrophils (PMID: 37503670). The molecular weight of NCDN is 78 kDa.

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