Anticorps Recombinant de lapin anti-NCDN

NCDN Recombinant Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, ELISA

Conjugaison

Non conjugué

CloneNo.

243146E2

N° de cat : 85730-1-RR

Synonymes

Neurochondrin, KIAA0607, NEDIES

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Galerie de données de validation

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  WB analysis using 85730-1-RR

  Various lysates were subjected to SDS PAGE followed by western blot with 85730-1-RR (NCDN antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours.

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  Affinity and Kinetic Characterization of 85730-1-RR

  Biolayer interferometry (BLl) kinetic assays of 85730-1-RR against Human NCDN were performed. The affinity constant is 1.35 nM.

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Applications testées

• Résultats positifs en WB: tissu cérébral de souris, tissu cérébral de rat, tissu cérébral humain fœtal

Dilution recommandée

• Western Blot (WB): WB : 1:5000-1:50000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Informations sur le produit

85730-1-RR cible NCDN dans les applications de WB, ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: NCDN Protéine recombinante Ag3859
• Nom complet: neurochondrin
• Masse moléculaire calculée: 729 aa, 79 kDa
• Poids moléculaire observé: 75-79 kDa
• Numéro d’acquisition GenBank: BC024592
• Symbole du gène: Neurochondrin
• Identification du gène (NCBI): 23154
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

NCDN protein (Neurochondrin) is a highly conserved 79 kDa adaptor protein, which was first discovered in 1997 and mainly expressed in the nervous system. NCDN protein plays an important role in neuronal differentiation, formation and maintenance of dendritic spines. It is involved in the development of synapses, neuronal differentiation and signal transduction, and maintains cell polarity by regulating dendritic morphogenesis and neural signal pathway. Recent studies have found that NCDN protein is expressed not only in neurons, but also in myeloid cells (such as neutrophils), and plays a role as a negative regulator of innate immunity. Mice lacking NCDN in myeloid cells are more immune to bacterial infection because of the increased reactivity of neutrophils (PMID: 37503670). The molecular weight of NCDN is 78 kDa.

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