Anticorps Monoclonal anti-NK1.1 (CD161)

NK1.1 (CD161) Monoclonal Antibody for FC

Hôte / Isotype

Mouse / IgG2a, kappa

Réactivité testée

souris

Applications

FC

Conjugaison

PE Fluorescent Dye

Publications(2)

CloneNo.

PK136

N° de cat : PE-65138

Synonymes

Klrb1a, CD161a, PK136, Nkrp1a, NK1.1

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Galerie de données de validation

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  FC experiment of mouse splenocytes using PE-65138

  1x10^6 C57BL/6 mouse splenocytes were surface stained with 0.2 ug PE Anti-Mouse NK1.1 (CD161) (PK136) (PE-65138, Clone:PK136) or 0.2 ug PE Mouse IgG2a Isotype Control (C1.18.4) (PE-65208, Clone: C1.18.4). Cells were co-stained with CoraLite® Plus 647 Anti-Mouse CD3. Cells were not fixed.

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Applications testées

• Résultats positifs en cytométrie: splénocytes de souris

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Applications publiées

• FC: See 2 publications below

Informations sur le produit

PE-65138 cible NK1.1 (CD161) dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Réactivité citée: souris
• Hôte / Isotype: Mouse / IgG2a, kappa
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: Cellules NK-1+ de rate et de moelle osseuse de souris
• Nom complet: killer cell lectin-like receptor subfamily B member 1A
• Numéro d’acquisition GenBank: BC120707
• Symbole du gène: NK1.1
• Identification du gène (NCBI): 17057
• Conjugaison: PE Fluorescent Dye
• Excitation/Emission maxima wavelengths: 496 nm, 565 nm / 578 nm
• Forme: Liquide
• Méthode de purification: Purification par affinité
• Tampon de stockage: PBS with 0.09% sodium azide and 0.5% BSA
• Conditions de stockage: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Informations générales

NK1.1 (CD161), also known as KLRB1 or NKR-P1A, is a type II transmembrane C-type lectin-like receptor and is expressed on the cell membrane as disulfide-linked homodimer (PMID: 8077657). It is expressed by the majority of NK cells and subsets of peripheral T cells, including both CD4+ and CD8+ T cells, and is expressed preferentially on adult T cells with a "memory" antigenic phenotype (PMID: 8077657; 22566826). Expression of CD161 correlates with the cytotoxic function of CD16+ NK cells, and ligation of CD161 with its ligand LLT1 inhibits NK cell cytotoxicity and cytokine secretion (PMID: 29686665).

Publications

Species	Application	Title
mouse	FC	Nat Nanotechnol; A bispecific nanosystem activates endogenous natural killer cells in the bone marrow for haematologic malignancies therapy; Authors - Yanqin Zhang
mouse	FC	Adv Sci (Weinh); EGR3 Inhibits Tumor Progression by Inducing Schwann Cell-Like Differentiation; Authors - Cai-Hong Chen

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