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Anticorps Recombinant de lapin anti-NKp46/NCR1

NKp46/NCR1 Recombinant Antibody for IF/ICC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

IF/ICC, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

242549C5

N° de cat : 85021-4-PBS

Synonymes

NCR 1, Natural killer cell p46-related protein, LY94, hNKp46, CD335

Galerie de données de validation

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  • Immunofluorescence (IF) / fluorescent staining of NK-92 cells using NKp46/NCR1 Recombinant antibody (85021-4-RR)

    IF Staining of NK-92 using 85021-4-RR (same clone as 85021-4-PBS)

    Immunofluorescent analysis of (4% PFA) fixed NK-92 cells using NKp46/NCR1/CD335 antibody (85021-4-RR, Clone: 242549C5 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 85021-4-PBS in a different storage buffer formulation.

Informations sur le produit

85021-4-PBS cible NKp46/NCR1 dans les applications de IF/ICC, Indirect ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Lapin / IgG
Clonalité Recombinant
Type Anticorps
Immunogène Protéine recombinante
Nom complet natural cytotoxicity triggering receptor 1
Masse moléculaire calculée34kDa
Symbole du gène NCR1
Identification du gène (NCBI) 9437
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par protéine A
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

NKp46, also known as natural cytotoxicity triggering receptor 1 (NCR1), is a type I transmembrane protein belonging to the immunoglobulin superfamily. NKp46 is a key activating receptor expressed on natural killer (NK) cells. It plays a key role in the innate immune response by recognizing and binding to viral hemagglutinins and other ligands on infected or tumor cells. NKp46 mediates cytotoxicity and cytokine production upon engagement with its ligands, contributing to the elimination of infected or malignant cells. Its expression and function are tightly regulated, and dysregulation of NKp46 has been implicated in various diseases, including viral infections, cancer, and autoimmune disorders. (PMID: 11234016; 29329948; 9730896; 9314561).

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