Anticorps Recombinant de lapin anti-NKp46/NCR1

NKp46/NCR1 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241804A12

N° de cat : 98198-1-PBS

Synonymes

Ncr1, mNKp46, Lymphocyte antigen 94, Ly94, CD335

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Galerie de données de validation

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  FC experiment of mouse splenocytes using 98198-1-RR (same clone as 98198-1-PBS)

  1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse NKp46/NCR1 Rabbit Recombinant Antibody (98198-1-RR, Clone: 241804A12) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with CoraLite® Plus 647 Anti-Mouse CD49b. Cells were not fixed. This data was developed using the same antibody clone with 98198-1-PBS in a different storage buffer formulation.

• 

  FC experiment of mouse splenocytes using 98198-1-RR (same clone as 98198-1-PBS)

  1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse NKp46/NCR1 Rabbit Recombinant Antibody (98198-1-RR, Clone: 241804A12)(red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98198-1-PBS in a different storage buffer formulation.

• 

  Affinity and Kinetic Characterization of 98198-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98198-1-RR against Mouse NKp46/NCR1 were performed. The affinity constant is below 1 pM.

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Informations sur le produit

98198-1-PBS cible NKp46/NCR1 dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: natural cytotoxicity triggering receptor 1
• Masse moléculaire calculée: 37kDa
• Numéro d’acquisition GenBank: NM_010746.3
• Symbole du gène: NKp46/NCR1
• Identification du gène (NCBI): 17086
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

NKp46, also known as NCR1 or CD335, is an Ig-like superfamily cell surface receptor that is highly conserved in mammals (PMID: 22021440). NKp46 is a type I transmembrane glycoprotein consisting of two extracellular Ig-like domains, a transmembrane domain, and an intracellular tail (PMID: 9730896). It is expressed on NK cells, rare T-cell subsets and a mucosal population of NKp46+ innate lymphoid cells (PMID: 9730896; 22021440). NKp46 is the major triggering receptor involved in the natural cytotoxicity (PMID: 10359120; 10092106; 15356098).

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