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Anticorps Recombinant de lapin anti-NLRP12

NLRP12 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

241838E11

N° de cat : 83123-6-PBS

Synonymes

PAN6, NALP12, NACHT, LRR and PYD domains-containing protein 12, Monarch-1, Monarch 1

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using NLRP12 Recombinant antibody (83123-6-RR)

    WB analysis using 83123-6-RR (same clone as 83123-6-PBS)

    Mouse liver tissue was subjected to SDS PAGE followed by western blot with 83123-6-RR (NLRP12 antibody) at dilution of 1:12000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83123-6-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 83123-6-RR

    Affinity and Kinetic Characterization of 83123-6-RR

    Biolayer interferometry (BLl) kinetic assays of 83123-6-RR against Human NLRP12 were performed. The affinity constant is 0.236 nM.

Informations sur le produit

83123-6-PBS cible NLRP12 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

Réactivité Humain, souris
Hôte / Isotype Lapin / IgG
Clonalité Recombinant
Type Anticorps
Immunogène NLRP12 Protéine recombinante Ag34281
Nom complet NLR family, pyrin domain containing 12
Masse moléculaire calculée 1061 aa, 120 kDa
Poids moléculaire observé 95-110 kDa
Numéro d’acquisition GenBankBC028069
Symbole du gène NLRP12
Identification du gène (NCBI) 91662
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Protein A purfication
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

NACHT, LRR and PYD domains-containing protein 12 (NLRP12) is also named as Monarch-1, NALP12, PYPAF7 and RNO. NLRP12 is as an essential cytosolic sensor for heme plus PAMPs-mediated PANoptosis, inflammation, and pathology (PMID: 37267949). NLRP12 drives inflammasome and PANoptosome activation, cell death, and inflammation in response to heme plus PAMPs or TNF. TLR2/4-mediated signaling through IRF1 induced Nlrp12 expression, which led to inflammasome formation to induce maturation of IL-1β and IL-18 (PMID: 37267949). NLRP12, a pyrin-containing NLR protein, is a negative regulator of innate immune activation and type I interferon (IFN-I) production (PMID: 36719379).

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