Anticorps Polyclonal de lapin anti-NLRP7

NLRP7 Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 27897-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis using 27897-1-AP (same clone as 27897-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 27897-1-AP (NLRP7 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27897-1-PBS in a different storage buffer formulation.

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  IHC staining of human spleen using 27897-1-AP (same clone as 27897-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human spleen tissue slide using 27897-1-AP (NLRP7 antibody) at dilution of 1:200 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27897-1-PBS in a different storage buffer formulation.

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  IHC staining of human spleen using 27897-1-AP (same clone as 27897-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human spleen tissue slide using 27897-1-AP (NLRP7 antibody) at dilution of 1:200 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27897-1-PBS in a different storage buffer formulation.

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Informations sur le produit

27897-1-PBS cible NLRP7 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: NLRP7 Protéine recombinante Ag27465
• Nom complet: NLR family, pyrin domain containing 7
• Masse moléculaire calculée: 112 kDa, 115 kDa, 118 kDa
• Poids moléculaire observé: 112 kDa
• Numéro d’acquisition GenBank: BC109125
• Symbole du gène: NLRP7
• Identification du gène (NCBI): 199713
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

NLRP7, also called NALP7 or PYPAF3, is a member of the NOD-like receptors (NLR), a family of proteins that plays a crucial role in the innate immune response. NLRP7 has been reported to emerge from NLRP2 gene. Similar to all inflammasomes, NLRP7 contributes to both pro- and an anti-inflammatory processes, depending on whether it functions in an inflammasome-dependent or independent pathway. The function of NLRP7 inflammasome has also been reported to depend on the master regulatory transcription factor protein that controls cellular inflammation, the NF-kB. In addition to its pro- and anti-inflammatory actions, NLRP7 plays a role in restricting intracellular bacterial replication and can also induce inflammasome assembly upon specific stimulation by FSL-1 (diacylated lipoprotein).

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