Anticorps Monoclonal anti-NMDAR2B/GRIN2B

NMDAR2B/GRIN2B Monoclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

1C5E12

N° de cat : 66565-1-PBS

Synonymes

GluN2B, GRIN2B, hNR3, NMDAR2B, NMDAR2B/GRIN2B, NR2B, NR3

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Galerie de données de validation

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  WB analysis of mouse brain using 66565-1-Ig (same clone as 66565-1-PBS)

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 66565-1-Ig (NMDAR2B/GRIN2B antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66565-1-PBS in a different storage buffer formulation.

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  WB analysis of rat brain using 66565-1-Ig (same clone as 66565-1-PBS)

  rat brain tissue were subjected to SDS PAGE followed by western blot with 66565-1-Ig (NMDAR2B/GRIN2B antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66565-1-PBS in a different storage buffer formulation.

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Informations sur le produit

66565-1-PBS cible NMDAR2B/GRIN2B dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: NMDAR2B/GRIN2B Protéine recombinante Ag16718
• Nom complet: glutamate receptor, ionotropic, N-methyl D-aspartate 2B
• Masse moléculaire calculée: 1484 aa, 166 kDa
• Poids moléculaire observé: 166 kDa
• Numéro d’acquisition GenBank: BC113620
• Symbole du gène: GRIN2B
• Identification du gène (NCBI): 2904
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine G
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

GRIN2B (also known as GluN2B or NMDAR2B) is a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. NMDA receptors are widely expressed in the central nervous system and play a major role in excitatory synaptic transmission and plasticity (PMID: 23223336). NMDA receptors large multi-subunit complexes arranged into heteromeric assemblies composed of four homologous subunits within a repertoire of over 10 different subunits: eight GluN1 isoforms, four GluN2 subunits (A-D) and two GluN3 subunits (A and B) (PMID: 21395862). Naturally occurring mutations within GRIN2B gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia.

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