Anticorps Polyclonal de lapin anti-NPC2

• Phare
• Validé par KD/KO

NPC2 Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 19888-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis using 19888-1-AP (same clone as 19888-1-PBS)

  HepG2 cells were subjected to SDS PAGE followed by western blot with 19888-1-AP (NPC2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 19888-1-PBS in a different storage buffer formulation.

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  IHC staining of human liver using 19888-1-AP (same clone as 19888-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 19888-1-AP (NPC2 Antibody) at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 19888-1-PBS in a different storage buffer formulation.

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  IHC staining of human liver using 19888-1-AP (same clone as 19888-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 19888-1-AP (NPC2 Antibody) at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 19888-1-PBS in a different storage buffer formulation.

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Informations sur le produit

19888-1-PBS cible NPC2 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: NPC2 Protéine recombinante Ag13719
• Nom complet: Niemann-Pick disease, type C2
• Masse moléculaire calculée: 151 aa, 17 kDa
• Poids moléculaire observé: 17-21 kDa
• Numéro d’acquisition GenBank: BC002532
• Symbole du gène: NPC2
• Identification du gène (NCBI): 10577
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Niemann-Pick Type C (NPC) disease is a lysosomal storage disorder characterized by accumulation of unesterified cholesterol and other lipids in the endolysosomal system. NPC disease results from a defect in either of two distinct cholesterol-binding proteins: a transmembrane protein, NPC1, and a small soluble protein, NPC2. NPC1 or NPC2 deficiency models showed that the function of these two proteins within lysosomes are linked closely. NPC2 is also named human epididymis-specific protein 1 (HE1), defects of which are the cause of Niemann-Pick disease type C2, characterized as a lysosomal storage disorder that affects the viscera and the central nervous system. Recent finding suggests that NPC2 may serve as a novel intracrine/autocrine factor that controls adipocyte differentiation and function as well as potential therapeutic target for the treatment of type 2 diabetes and related metabolic disorders.

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