Anticorps Polyclonal de lapin anti-NPHP5/IQCB1

NPHP5/IQCB1 Polyclonal Antibody for WB, IP, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IP, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 15747-1-PBS

Synonymes

IQCB1, NPHP5, IQ calmodulin-binding motif-containing protein 1, IQ motif containing B1, IQCB 1

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Galerie de données de validation

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  WB analysis using 15747-1-AP (same clone as 15747-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 15747-1-AP (NPHP5,IQCB1 antibody) at dilution of 1:2500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15747-1-PBS in a different storage buffer formulation.

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  WB analysis using 15747-1-AP (same clone as 15747-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 15747-1-AP (NPHP5/IQCB1 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15747-1-PBS in a different storage buffer formulation.

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  IP experiment of HEK-293 using 15747-1-AP (same clone as 15747-1-PBS)

  IP result of anti-NPHP5/IQCB1 (IP:15747-1-AP, 4ug; Detection:15747-1-AP 1:1000) with HEK-293 cells lysate 1280 ug. This data was developed using the same antibody clone with 15747-1-PBS in a different storage buffer formulation.

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Informations sur le produit

15747-1-PBS cible NPHP5/IQCB1 dans les applications de WB, IP, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: NPHP5/IQCB1 Protéine recombinante Ag8203
• Nom complet: IQ motif containing B1
• Masse moléculaire calculée: 598 aa, 69 kDa
• Poids moléculaire observé: 69 kDa
• Numéro d’acquisition GenBank: BC005806
• Symbole du gène: IQCB1
• Identification du gène (NCBI): 9657
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

IQCB1, also known as NPHP5, is a nephrocystin protein that interacts with calmodulin and the retinitis pigmentosa GTPase regulator protein. It has a central coiled-coil region and two calmodulin-binding IQ domains. Localized to the primary cilia of renal epithelial cells and connecting cilia of photoreceptor cells, IQCB1 is thought to play a role in ciliary function. Mutations in this gene result in Senior-Loken syndrome type 5, a juvenile disorder characterized by defects in the waste filtering system of the kidney, as well as retinal degradation.

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