Anticorps Monoclonal anti-NPHP5/IQCB1

NPHP5/IQCB1 Monoclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

2A9F4

N° de cat : 68404-1-PBS

Synonymes

IQ motif containing B1, IQCB1, KIAA0036, Nephrocystin 5, PIQ, SLSN5

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Galerie de données de validation

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  WB analysis using 68404-1-Ig (same clone as 68404-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 68404-1-Ig (NPHP5,IQCB1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68404-1-PBS in a different storage buffer formulation.

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Informations sur le produit

68404-1-PBS cible NPHP5/IQCB1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG2a
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: NPHP5/IQCB1 Protéine recombinante Ag8203
• Nom complet: IQ motif containing B1
• Masse moléculaire calculée: 598 aa, 69 kDa
• Poids moléculaire observé: 69 kDa
• Numéro d’acquisition GenBank: BC005806
• Symbole du gène: IQCB1
• Identification du gène (NCBI): 9657
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

IQCB1, also known as NPHP5, is a nephrocystin protein that interacts with calmodulin and the retinitis pigmentosa GTPase regulator protein. It has a central coiled-coil region and two calmodulin-binding IQ domains. Localized to the primary cilia of renal epithelial cells and connecting cilia of photoreceptor cells, IQCB1 is thought to play a role in ciliary function. Mutations in this gene result in Senior-Loken syndrome type 5, a juvenile disorder characterized by defects in the waste filtering system of the kidney, as well as retinal degradation.

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