Anticorps Polyclonal de lapin anti-NRK1

NRK1 Polyclonal Antibody for WB, IP, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, IP, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 23805-1-PBS

Synonymes

C9orf95, Nicotinamide riboside kinase 1, NMRK1, Ribosylnicotinic acid kinase 1

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Galerie de données de validation

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  WB analysis using 23805-1-AP (same clone as 23805-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 23805-1-AP (NRK1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 23805-1-PBS in a different storage buffer formulation.

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  IP experiment of mouse kidney using 23805-1-AP (same clone as 23805-1-PBS)

  IP result of anti-NRK1 (IP:23805-1-AP, 4ug; Detection:23805-1-AP 1:3000) with mouse kidney tissue lysate 3400 ug. This data was developed using the same antibody clone with 23805-1-PBS in a different storage buffer formulation.

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Informations sur le produit

23805-1-PBS cible NRK1 dans les applications de WB, IP, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: NRK1 Protéine recombinante Ag20746
• Nom complet: chromosome 9 open reading frame 95
• Masse moléculaire calculée: 199 aa, 23 kDa
• Poids moléculaire observé: 23 kDa
• Numéro d’acquisition GenBank: BC001366
• Symbole du gène: C9orf95
• Identification du gène (NCBI): 54981
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purifié par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

NRK1 (Nicotinamide riboside kinase 1) is necessary and rate-limiting for the use of exogenous NR and NMN for NAD þ synthesis. Functionally, NRK1 activity restrains CD4+ T cell activation and cytokine production and promotes survival. These activities are linked to increased NRK1 expression in the cytoplasm, where it locally elevates NAD/H levels (PMID: 27725675, 29678570).

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