Anticorps Recombinant de lapin anti-TrkA

TrkA Recombinant Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, ELISA

Conjugaison

Non conjugué

CloneNo.

240440D12

N° de cat : 83477-7-PBS

Synonymes

NTRK1, Trk A, TRK, p140 TrkA, MTC

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Galerie de données de validation

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  WB analysis of K-562 using 83477-7-RR (same clone as 83477-7-PBS)

  K-562 cells were subjected to SDS PAGE followed by western blot with 83477-7-RR (TrkA antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83477-7-PBS in a different storage buffer formulation.

• 

  WB analysis of SH-SY5Y using 83477-7-RR (same clone as 83477-7-PBS)

  SH-SY5Y cells were subjected to SDS PAGE followed by western blot with 83477-7-RR (TrkA antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83477-7-PBS in a different storage buffer formulation.

• 

  Affinity and Kinetic Characterization of 83477-7-RR

  Biolayer interferometry (BLl) kinetic assays of 83477-7-RR against Human NTRK1 were performed. The affinity constant is below 1 pM.

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Informations sur le produit

83477-7-PBS cible TrkA dans les applications de WB, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: TrkA Protéine recombinante Ag32759
• Nom complet: neurotrophic tyrosine kinase, receptor, type 1
• Masse moléculaire calculée: 88 kDa
• Poids moléculaire observé: 140 kDa
• Numéro d’acquisition GenBank: NM_001007792
• Symbole du gène: NTRK1
• Identification du gène (NCBI): 4914
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

NTRK1(Neurotrophic tyrosine kinase receptor 1) is located on chromosome 1q23.1 and is responsible for a rare genetic disorder, CIPA (congenital insensitivity to pain with anhidrosis) (PMID: 37907480). As a neurotrophin receptor, NTRK1 is abundantly expressed in human neuronal tissues and plays an integral role in the development and function of the human nervous system (PMID: 27843590). NTRK1 also regulates the survival and proliferation of cholinergic neurons (PMID: 20054812).

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