Anticorps Polyclonal de lapin anti-NUDT18

NUDT18 Polyclonal Antibody for IF/ICC, IP, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

IF/ICC, IP, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 17318-1-PBS

Synonymes

MTH3, Nucleoside diphosphate-linked moiety X motif 18, EC:3.6.1.58, 8-oxo-dGDP phosphatase NUDT18, 7,8-dihydro-8-oxoguanine phosphatase

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Galerie de données de validation

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  IP experiment of THP-1 using 17318-1-AP (same clone as 17318-1-PBS)

  IP result of anti-NUDT18 (IP:17318-1-AP, 4ug; Detection:17318-1-AP 1:500) with THP-1 cells lysate 2480 ug. This data was developed using the same antibody clone with 17318-1-PBS in a different storage buffer formulation.

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  IF Staining of THP-1 using 17318-1-AP (same clone as 17318-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed THP-1 cells using NUDT18 antibody (17318-1-AP) at dilution of 1:400 and Multi-rAb CoraLite ® Plus 488-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR002). This data was developed using the same antibody clone with 17318-1-PBS in a different storage buffer formulation.

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Informations sur le produit

17318-1-PBS cible NUDT18 dans les applications de IF/ICC, IP, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: NUDT18 Protéine recombinante Ag11292
• Nom complet: nudix (nucleoside diphosphate linked moiety X)-type motif 18
• Masse moléculaire calculée: 323 aa, 36 kDa
• Poids moléculaire observé: 36 kDa
• Numéro d’acquisition GenBank: BC016902
• Symbole du gène: NUDT18
• Identification du gène (NCBI): 79873
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

8-oxo-dGDP phosphatase NUDT18, also known as MTH3, belongs to the Nudix hydrolase family that eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of various nucleotide substrates, cofactors, and signaling molecules (PMID: 35732208, 22556419). NUDT18 is specifically active against 8-oxo-dGDP and hardly cleaves 8-oxo-dGTP. NUDT18 is markedly elevated expression in noncancerous cell lines in comparison to cancerous counterpart, and NUDT18 deficient cells have been reported to exhibit a noticeably reduced proliferation rate (PMID: 38944687).

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