Anticorps Recombinant de lapin anti-Nectin-2/CD112

Nectin-2/CD112 Recombinant Antibody for FC (Intra)

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC (Intra)

Conjugaison

APC Fluorescent Dye

CloneNo.

241798A11

N° de cat : APC-FcA98231

Synonymes

CD112, Herpes virus entry mediator B, HveB, mHveB, Mph

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Galerie de données de validation

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  FC experiment of NIH/3T3 using APC-FcA98231

  1x10^6 NIH/3T3 cells were surface stained with 0.1 ug APC Anti-Mouse Nectin-2/CD112 Rabbit RecAb (APC-FcA98231, Clone: 241798A11) or 0.1 ug APC Rabbit IgG Isotype Control RecAb (APC-FcA98136, Clone: 240953C9). Cells were not fixed.

• 

  FC experiment of NIH/3T3 using APC-FcA98231

  1x10^6 NIH/3T3 cells were surface stained with 0.1 ug APC Anti-Mouse Nectin-2/CD112 Rabbit RecAb (APC-FcA98231, Clone: 241798A11) (red) or 0.1 ug APC Rabbit IgG Isotype Control RecAb (APC-FcA98136, Clone: 240953C9) (blue). Cells were not fixed.

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Applications testées

• Résultats positifs en FC (Intra): cellules NIH/3T3,

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

APC-FcA98231 cible Nectin-2/CD112 dans les applications de FC (Intra) et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Nectin-2/CD112 Protéine recombinante Eg2019
• Nom complet: poliovirus receptor-related 2
• Masse moléculaire calculée: 57 kDa
• Numéro d’acquisition GenBank: NM_008990.3
• Symbole du gène: Nectin-2/CD112
• Identification du gène (NCBI): 19294
• Conjugaison: APC Fluorescent Dye
• Excitation/Emission maxima wavelengths: 650 nm / 660 nm
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.09% sodium azide and 0.5% BSA
• Conditions de stockage: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Informations générales

Nectin 2, also named as PVRL2, CD112, HVEB, PRR2 and PVRR2, is an adhesion molecule widely expressed in cell lines of different lineages, including hematopoietic, neuronal, endothelial and epithelial cells. CD112 belongs to a new family of immunoglobulin-like molecules that includes four members (CD111, CD112, PRR3 and CD155) sharing an ectodomain made of three Ig domains, of V and C types. CD112 is expressed in the myelo-monocytic and megakaryocytic hematopoietic lineages and the function in hematopoiesis is currently unknown. CD112 is an intercellular homophilic adhesion. CD112 localizes specifically at adherents junctions via its cytoplasmic interaction with the scaffold F-actin binding protein afadin. Disruption of the murine CD112 gene leads to infertility of male mice with morphologically aberrant spermatozoa. CD112 mediates entry of some alphaherpesvirus mutants (also named HveB) via its V domain. CD112 is involved in cell to cell spreading of viruses.

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